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In addition, the differences between the two co-agonists may be attributable to unique receptor pharmacology with tirzepatide engaging the GLP-1R in a manner different from GLP-1, including reduced beta-arrestin recruitment and internalization 47,48,50
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Current pricing data from Canadian pharmacies shows significant variation in monthly costs for brand-name GLP-1 medications, with Ozempic and Wegovy ranging from $300 to $570 CAD per month depending on dose, pharmacy, and province
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